Custom Structural Variant Controls are synthetic nucleic acids that contain specific sequence variations, such as insertions, deletions, inversions, or translocations. They are used as reference materials or quality controls for next-generation sequencing (NGS) or polymerase chain reaction (PCR)-based testing methods.
The ctDNA fragments are around 150bp, carrying mutations at random locations on the fragments. The Allele Frequencies can be from 0.02% to 5%, determined by ddPCR. The wildtype cfDNA is either from normal cell line or normal patient cells. The cfDNA profile is below:
We provide cfDNAs from two different individual normal patients (or, if preferred, normal cell lines) mixed at any desired ratio for Molecular Testing for Solid Organ Allograft Rejection. The cfDNA profile is below:
Custom RNA and DNA Viruses, Bacteria and Fungi are non-pathogenic microorganisms that contain specific genetic sequences, such as genes, promoters, or markers. They are used as reference materials or quality controls for molecular testing methods, such as polymerase chain reaction (PCR)